The Baroque church of San Domenico was founded in 1233 by Roffredo Epifanio, a famous Benevento jurist from the line of Lombard princes. Attached to it is a convent, now the site of the Rectorate of the University of Sannio. Epifanio made a gift of everything to the Dominicans, who then gave the convent to the nuns of the same order. Surrounding this convent were several churches, including that of Saints Simon and Judas, which belonged to the Morra princes: at this church a well was buried in which more than 600 Beneventanians, who perished in a single day, were buried in the struggles between Guelphs and Ghibellines. The church was completely rebuilt after the earthquake of June 5, 1688: laying the foundation stone was Cardinal Orsini. Further damage followed due to other earthquakes. Its garden houses Mimmo Paladino’s Hortus Conclusus.