The church was built around 1630-1638 by the Confraternity of the Holy Rosary, which had been in existence for a few decades. Following the foundation of the adjacent Poor Clare convent, it was used by cloistered nuns in the 17th and 18th centuries. The church, built in the Baroque style, stands in the Piscobia district, a very short distance from the Cathedral of the Immaculate Conception and the seat of the Curia. The main facade is nearly square, completed at the top by a simple cornice with a wrought iron cross of later date. On either side of the front door are two circular windows that illuminate the first two chapels, while above the front door is a long window that gives light to the chancel. The interior consists of a barrel-vaulted hall with three side chapels on each side, which are also barrel-vaulted; the chancel is raised above the nave and is preceded by a triumphal arch. The interior contains statues from the 17th and 18th centuries and a large naturalistic fresco from 1699 in the first chapel on the right, known as the Chapel of the Souls.
