The Church of Santa Margherita was built in 1725 with bequests from the Setzu-Puxeddu family. In Samassi, popular devotion to the saint has very ancient origins, as she was credited with ending the plague through her intercession.
The church is located in the historic center. The exterior of the building is characterized by an open loggia on three sides: the front opening is said to be pointed while the side openings are round. Above the porch is the small bell gable (the only original part), which not only embellishes the facade in its simplicity, but also suggests that originally the church was entirely made of stone. The interior appears simple and modest, showing Greco-Byzantine influences with a single nave covered with wooden trusses. At the end of the nave is an altar dating from the 1700s made of inlaid marble. In ancient times, the floor was made of Sardinian tiles and the ceiling consisted of reeds and boards. In 2008, the church underwent a thorough restoration, recovering the ancient wooden ceiling and restoring the painting of the exterior loggia to new life.
