The 17th-century church of St. John, located on the street of the same name, first officially appears in a document from 1415. It was severely damaged by fire in 1750, but by 1752 it had been rebuilt with its present configuration.
The simple gabled elevation, crowned by hanging arches revealing more recent interventions, has a beautiful splayed portal with capitals with floral reliefs. It has a rectangular plan with a single barrel-vaulted nave, three small chapels on each side, and a raised chancel.
Inside it preserves interesting paintings and sculptures including the valuable simulacra of Our Lady of Sorrows and the Crucifix.
The church also houses one of the oldest existing pipe organs in Cagliari, dated 1752.
In 1697 the Archconfraternity of Solitude, founded in 1603, moved there from its former home, the now-destroyed church of the Trinitarian fathers of St. Bardilius, once located at the foot of Bonaria Hill.
The purpose of the Archconfraternity, linked to that of the Trinity in Rome, was the redemption of Christian slaves who had fallen into the hands of the infidels. In more recent times it turns its efforts to various social and volunteer activities; it also maintains the traditional Holy Week procession.