Palazzo Turchi di Bagno, one of the buildings of the Rossettian Quadrivio, was built in 1493 by Biagio Rossetti. Construction began, under the direct supervision of Duke Ercole I d’Este, at the behest of the Turchi family. The entire exterior is in face brick, distinguished by a few elements: the corner pilaster in Istrian stone, the entrance portal and the terracotta cornice. The palace also owes its name to the Guidi family of Bagno, who became owners through a marriage. The Turchi di Bagno family ceded the building to the State Property Office in 1933.
During the bombing of World War II, the palace suffered extensive damage.
The University of Ferrara, to which the State Property Office, after the war, ceded the palace for perpetual use, has designated it as the seat of the Institutes of Botany (with adjoining Garden), Mineralogy, Geology and Geography.